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A poster session titled “Oncogenic Growth Factors and Signal Transducers” took place at the 107th American Association for Cancer Research (AACR) annual meeting in Washington, DC, USA on Sunday 3rd April.
Uncontrolled activation of genes involved in the Phosphatidylinositol 3-Phosphate (PI3P) pathway via PI3K/AKT/mTOR are associated with oncogenic activity and poor survival.1 Additionally, dysregulation of AMP-Activated Protein Kinase (AMPK), a regulator of cell homeostasis, has been reported to play a role in Acute Myeloid Leukemia (AML).2
Mariachiara Abbenante from the University of Bologna, Bologna, Italy, and colleagues investigated the effect of PI3P and AMPK pathways in AML. In total, 208 newly diagnosed AML patients were screened for TP53, FLT3, NPMI, IDH1, IDH2, and DNMTA mutations.
In summation, alterations in the PI3P and cAMP pathways are associated with poor prognosis in AML patients. Moreover, alterations in the cAMP pathway is associated with therapy resistance in AML.
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