All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View AML content recommended for you
At the 60th American Society of Hematology Annual Meeting & Exposition, Mohamed L. Sorror from the Fred Hutchinson Cancer Research Center, Seattle, US, presented data from the first prospective multi-center longitudinal study, dating from first presentation of adult patients with acute myeloid leukemia (AML) who were treated at one of 13 different referral centers that provide both AML treatment and hematopoietic cell transplantation (HCT). The survival of patients who received and did not receive HCT was compared.
In this study, 695 patients with AML (90.5%) or myelodysplastic syndrome/myeloproliferative neoplasm (9.5%) were enrolled in this study. According to the European LeukemiaNet (ELN) 2010 cytogenetic risk classification, 15.5%, 49.6% and 34.8% of patients were classified as low-, intermediate- and high-risk, respectively.
The researchers identified risk factors associated with mortality in the overall population. These risk factors were used to develop multivariate models examining the association between HCT and mortality.
In summary, after adjusting for key AML-specific and patient-specific variables the observed benefit of HCT over non-HCT therapies in reducing mortality rates among patients with AML was negated.
The speaker suggested that the findings of their study “might reflect an improvement in supportive care and non-HCT therapies, a relatively high non-relapse mortality early after HCT and the need for longer follow-up to demonstrate an adjusted benefit of HCT, and the high selectivity of the transplant eligibility process, as we accounted here for variables that are often ignored in genetic assignment randomized studies.”
References