All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View AML content recommended for you
There is a paucity of studies evaluating the impact of conditioning regimen on post-transplant outcomes of secondary acute myeloid leukemia (sAML) patients with antecedent hematologic malignancy. Bipin Savani from the Vanderbilt University Medical Center, Nashville, TN, presented at the 44th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), results from a retrospective study which compared the outcomes of sAML patients who underwent allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative (MAC) or reduced intensity conditioning (RIC).
Using the Acute Leukemia Working Party registry, 549 sAML patients who underwent first allo-HSCT between 2000–2016 either from a matched related (MRD), matched unrelated (MUD), haploidentical donor or cord blood transplant were included in this study. Patients were administered either MAC (n = 258, median age at transplant = 47.8 years) or RIC (n = 291, median age at transplant = 55.9 years). Prior autologous HCT was performed in 35.6% (91/258) of patients in the MAC group and 40.6% (118/291) of patients in the RIC group.
It was also observed in this study that “prior hematologic diagnosis and donor type had no impact on outcomes”. The speaker noted that the study is limited by its retrospective nature but concluded, however, that the study indicates that “patients with sAML with prior hematologic malignancy treated with RIC allo-HCT have a lower risk of NRM and improved LFS, OS, and GFRS”.
References