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On Saturday 3rd December, at the 58th Annual Meeting & Exposition of the American Society of Hematology (ASH) in San Diego, CA, there was a gripping session focusing on “Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation.”
Guillermo Garcia-Manero, MD, of the Department of Leukemia at The University of Texas M.D. Anderson Cancer Center, Houston, USA, presented the key findings from a phase II study of pracinostat and azacitidine. Pracinostat is a potent oral Class I, II, IV Histone Deacetylase (HDAC) inhibitor and azacitidine (AZA) is a novel hypomethylating agent. Garcia-Manero et al. investigated the combination of these agents in 50 older patients (median age 75 years) unable to undergo induction chemotherapy.
The findings were:
The authors concluded that pracinostat + AZA led to a high rate of response in elderly patients with AML. Furthermore, the responses were durable and observed irrespective of age, cytogenetic risk, ECOG performance status, and de novo or secondary AML.
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