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Outcomes of pediatric patients with acute myeloid leukemia (AML) have significantly improved over the past several decades with overall survival (OS) rates now approaching 70%.1 Despite this improvement, anthracycline-associated cardiotoxicity, including left ventricular systolic dysfunction (LVSD), remains a serious risk for this patient population. Kelly D. Getz, PhD, of the Perelman School of Medicine, University of Pennsylvania, PA, USA, and colleagues analyzed pediatric patients with AML treated as part of COG AAML0531 trial in order to evaluate the independent effects of early-onset cardiotoxicity on event-free survival (EFS) or OS.2 The study was published in the Journal of Clinical Oncology on 1 January 2019.
The AAML0531 trial enrolled patients aged 30 or younger who were treated with intravenous infusions of daunorubicin and mitoxantrone. Cardiotoxicity was defined as grade 2 or higher LVSD on the basis of Common Terminology Criteria for Adverse Events definitions. Adverse events during a 5-year follow-up were monitored among 1,022 pediatric patients with AML.
The study authors concluded that “early treatment-related cardiotoxicity may be associated with decreased EFS and OS. Cardioprotective strategies are urgently needed to improve relapse risk and both short- and long-term mortality outcomes.”
These findings are important to better understand cardiotoxicity risk factors and to reduce anthracycline-induced left ventricular dysfunction in children with AML. This significant decrease in EFS and its effect on OS highlights the necessity of prospective clinical trials to evaluate prophylactic interventions.
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